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NAGWA ABDEL MEGUID

Researcher, Egypt

Dr. Nagwa Abdel Meguid is a professor of human genetics and head of the Department of Research on Children with Special Needs at the National Research Center (NRC) in Egypt.  She holds a Ph.D. in Human Genetics, and she is a Senior Geneticist at the Genetics Institute, Pasadena, California; a fellow of Uppsala University, Sweden.  She was one of five selected scientists to win the outstanding L’Oreal UNESCO Award for women in Science for Africa & Middle East (2002). She has used her expertise to identify and describe several novel genetic syndromes. She added new syndromes to the medical literature. She was given the Distinctive Arab Female Scientist Prize by the Arabian Gulf University, Bahrain, May, 2009. She was also given the National Award for Scientific Excellence in Advanced Technology in 2009. She is the head and running a Clinic for children with special needs in the NRC. She is one of the pioneers who accurately diagnose, delineate and publish autosomal recessive disorders in Egyptians as a consequence of the high prevalence of consanguinity. She shared in the establishment of epidemiological data for malformations at birth in Egyptians and for mental retardation. On the other hand she is the head of the laboratory of research in DNA and biochemical changes in genetic disorders. She participated in determining the spectrum of gene mutations causing common genetic disorders in Egypt (phenylketonuria, Duchenne muscular dystrophy, congenital snsorineural hearing loss and fragile-X syndrome) thus suggesting programs for their prevention by heterozygous detection and prenatal diagnosis. She is the first one to delineate the prevalence of FX mutation among Egyptian males which was 0.9 per 1000. Moreover, it was 6.4% among mentally subnormal males.

In addition, Prof. Meguid initiates a special clinic for early intervention in the Medical Service Unit at the National Research Centre. She applied special evaluation programs to teach and assess the cognitive, language and motor skills.

Prof. Meguid is actively involved in training and teaching young Physicians and scientists through a number of teaching and administrative posts. She also reaches out to her community by offering lectures to parents, schools and health care workers in Cairo and distant governorates and writing newspaper articles to help increase awareness of genetic disorders and the value of genetic counseling. Peer Reviewer for Scientific Journals such as ; Disease Marker Journal and Neuroscience Letters… She is a member in the National Council for Women in Science and Technology, a member in the Bio-Ethics Society of UNESCO, member of the International Jury L’OREAL-UNESCO Awards « For Women in Science » 2008 & 2009.  Member of TOWAS, member of Neuroinsight Foundation for Brain Research Initiatives, Canada..Principal Investigator of the Candian- Egyptian Neurodevelopmental Study. Delegate at the UNESCO-affiliated World Academy of Young Scientists (WAYS). She is the organizing member of the Arab Women Association for Research and Development (AWARD). She has extensive experience in training postgraduate students. She supervised around 25 Ph. D. students and 27 master theses in Medicine and Science in the fields of human genetics, Neurology and psychiatry. She has more than 120 National & International publications in the field of Human Genetics.

 

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Selected Main International Publications:

         

  1. Hamed RR, Maharem TM, Meguid, N. A., Sabry GM, Abdalla AM, Guneidy RA. (2011): Purification and biochemical characterization of glutathione S-transferase from Down Syndrome and normal children erythrocytes: A comparative study. Res Dev Disabil 32(5):1470-82.

      http://www.ncbi.nlm.nih.gov/pubmed/21377322

 

  1. Meguid, N. A., Fahim C, Uicheul Y, Nashaat N, Samir A, Mancini-Marie A,

            Brandner C, Evans AC. (2010): Brian morphology in autism and Fragile X
             Syndrome correlates with Social IQ. J Child Neurol. 25 (5):599-608
 http://www.ncbi.nlm.nih.gov/pubmed/20110214

 

  1. Meguid, N. A., Adel Ferig Hashish, Mona Anwar, Gloria Sidhom (2010): Assessment of 25-Hydroxy and 1, 25-Dihydroxy Vitamin D in Egyptian Children with Autism. J Altern Complement Med. 16 (6):641-5.  http://www.ncbi.nlm.nih.gov/pubmed/20569030

 

  1. Meguid, N. A., Ahmed A. Dardir , Ehab R. Abdel-Raouf & Adel Hashish  (2010): Evaluation of Oxidative Stress in Autism: Defective Antioxidant Enzymes and Increased Lipid Peroxidation. Biol Trace Elem Res, accepted for publication.       http://www.ncbi.nlm.nih.gov/pubmed/20845086

 

  1. Meguid, N. A., Dardir AA, El-Sayed EM, Ahmed HH, Hashish AF, Ezzat A.(2010): Homocysteine and oxidative stress in Egyptian children with Down syndrome. Clin Biochem. 43(12): 963-967. http://www.ncbi.nlm.nih.gov/pubmed/20450901

       

  1. Mostafa K. , Amr M. Karim, Laila S.Hanna, Lamia A. El Husseiny, Medhat El

Sahar, Hanan A. Abdel Menem, Meguid, N. A. (2009):          Methylenetetrahydrofolate  reductase gene polymorphisms and the risk of
colorectal carcinoma in a sample of  Egyptian individuals. Cancer           Biomarkers, 5: 1-8.
http://www.ncbi.nlm.nih.gov/pubmed/20037199

  1. Cherine Fahim, Meguid, N. A, Alan C Evans (2009): Anterior to posterior

             limb of the internal capsule morphology in fragile X syndrome.
             Developmental Medicine & Child Neurology, 51: 838–842
 http://www.ncbi.nlm.nih.gov/pubmed/19747282

 

  1. Meguid, N. A, Hazem M. Atta, Amr S.Gouda  , Rehab O .Khalil (2008): Role of polyunsaturated fatty acids in the management of Egyptian 

            Children with Autism.  J Clinical Biochemistry, 41: 1044–1048
http://www.ncbi.nlm.nih.gov/pubmed/18582451

 

  1. Meguid, N. A,, Ahmed A. Dardir, Mohamed Khass, Lamia Hossieny, Afaf Ezzatc ;  Mostafa K. El Awady (2008): MTHFR genetic polymorphism as a risk factor in  Egyptian mothers with Down syndrome children. Disease Markers, 24(1):19-26

      http://www.ncbi.nlm.nih.gov/pubmed/18057532

                                             

  1. Bassam R. Ali, Steve Jeffery, Neha Patel, Meguid, N. A, Michael A.

               Patton, Ali R. Afzal (2007): Novel Robinow syndrome causing mutations
               in the frizzled-like domain of ROR2 are retained in the endoplasmic
               reticulum.  Human Genetics, 122:389–39
              http://www.ncbi.nlm.nih.gov/pubmed/17665217

 

  1. Meguid, N. A., Katoury,A., Abdel-Salam,G, Ruby,M., Afifi,H. (2004):

                Growth Charts for Egyptian children with Down syndrome: (0-36
                months).  Eastern Mediterranean Health Journal, 10:106-115
               http://www.ncbi.nlm.nih.gov/pubmed/16201715

  1. Abdel Salam,GH.; Zaki,M.; Lebon P.; Meguid, N. A. (2004):

               Aicardi-Goutieres syndrome: Clinical and neuroradiological  findings
               of  new 10 cases. Acta  Paediatr 93: 929-936, 2004
               http://www.ncbi.nlm.nih.gov/pubmed/15303808

  1. El-Awad, M.; El-Shater, S.; Ragaa, E.; Atef, K.; Meguid, N. A. (2004):

                Molecular study on Y chromosome microdeletions in Egyptian males
                with idiopathic  infertility. Asian J.  Androl, 6: 53-57
                 www.biomedexperts.com/Profile.bme/361520/Mostafa                         

 

  1. Meguid, N. A., Tentany,A., Mazen,I (2003): Transposition of external  

genitalia and associated malformations. Clinical Dysmorphology, 11: 1-5
               http://www.ncbi.nlm.nih.gov/pubmed/12514368

                

  1. Meguid, N. A. Ashour, A. (2001): Holoprosencephaly and split Hand/foot:

               Additional case with this rare association.Clinical Dysmorphology,
               10(4): 277-280.
               http://www.ncbi.nlm.nih.gov/pubmed/11666003

 

 

  1. Meguid, N. A., Afifi,H., Khoulosy,N. (2001): Evaluations of SOD,GTpx

               enzymes and Cu,Ze,Sel trace elelments in Egyptian Children with DS.
               Biological Trace Element Research, 81: 21- 28
               http://www.ncbi.nlm.nih.gov/pubmed/11508329
 
         

  1. Meguid, N. A., Zaki,M, Hammad,S. (2001): Premarital investigation: Effect  

   of genetic counselling. Eastern Mediterranean Health J, 6, 2:652-660
                http://www.ncbi.nlm.nih.gov/pubmed/11794071
                     

  1. Effat,L., Harouni,A., Khalda M., Meguid, N. A. (2000): Screening of    

Dysrophin gene deletions in Egyptian Patients with DMD muscular   dystrophies. Disease Markers, 16(3-4):125-129.
               http://www.ncbi.nlm.nih.gov/pubmed/11381192

            

  1. Temtamy,S.A., Ismail,S., Meguid, N. A. (2000): Lenz microphthalmia

               syndrome: Three additional cases with rare associated anomalies. 
               Genetic Counseling, 11, (2), 147-152
               http://www.ncbi.nlm.nih.gov/pubmed/10893665
 

  1.   Bassyouni H., Afifi H, El-Awady M, Meguid, N. A. (2000):

  Mucopolysaccharidosis type I: Clinical & biochemical Study. Eastern  
  Mediterranean Health Journal, 6, 2/3: 359-366.
  http://www.ncbi.nlm.nih.gov/pubmed/11556024

  1. Effat,L., Kuzmin,A., Kasem,N, Meguid, N. A., Kotb, S.,Eisensmith,L,

               Temtamy,S., Rushdi, S., Woo, S., El-Awady, M. (1999):  Haplotypes
               And mutations of the PAH locus in Egyptian families with PKU.
               European J. of  Human Genetics, 2. 259-262.
               http://www.ncbi.nlm.nih.gov/pubmed/10196714

 

  1. Temtamy,S.A., Meguid, N. A., Ismail,S.I., Ramzy,M.I. (1998). A new

                multiple congenital  anomaly, mental retardation syndrome with
                preaxial  brachydactyly, hyperphalangism, deafness and orodental
                anomalies. Clin Dysmorphol, 7 (4) : 249-255.         
               http://www.ncbi.nlm.nih.gov/pubmed/9823490

  1. Meguid, N. A., Afifi,H.H., Ramzy,M.I., Hindawy,A., Temtamy,S.A.(1997):

               GAPO syndrome: First Egyptian case with ultrastructural changes in the
               gingiva. Clin. Genet. 52: 110-115.   
               http://www.ncbi.nlm.nih.gov/pubmed/9298746
  

  1. Temtamy,S.A., Meguid, N. A., Mahmoud,A., Afifi,H., Gerzawy,A.,    

    Zaki,M. (1996): COFS syndrome with familial 1;16 translocation. Clin.
    Genet. 50: 240-243.
  http://www.ncbi.nlm.nih.gov/pubmed/9001808

 

  1. Temtamy,S.A., Kandil,M.R., Demerdash,A.M., Hassan,W.A., Meguid, N. 

A.,  Afifi,H. H. (1994): An epidemiological/genetic study of mental  subnormality in Assiut Governorate Egypt. Clin. Genet. 46:347-351.
               http://www.ncbi.nlm.nih.gov/pubmed/7889643
 

  1. Temtamy,S.A., Aboul-Ezz,E., Sinbawy A; Meguid N (1994): Orodental, ear

    and eye anomalies in Egyptian Brachmann de Lange syndrome. The J. of    
    the Egyptian Public Health Association, LXIX (3-4): 163-183.
    http://www.ncbi.nlm.nih.gov/pubmed/17265636

  1. Meguid, N. A. (1993): Frontonasal dysplasia, lipoma of the corpus callosum 

and  tetralogy of Fallot. Clin.Genet. 44: 95-97.    http://www.ncbi.nlm.nih.gov/pubmed/8275566

  1.    Meguid, N. A., Habibian,R. (1992): Isodicentric chromosome 18 in an

        abnormal infant using chromosome specific DNA probe.Clin. Genet.
        41: 225-228.
        http://www.ncbi.nlm.nih.gov/pubmed/1606710

         
  1. Meguid, N. A., Temtamy,S.A. (1991): Neu-Laxova syndrome in two  

   Egyptian families.  Am. J. Med. Genet. 41:30-31.
               http://www.ncbi.nlm.nih.gov/pubmed/1951459

  1. Temtamy,S.A., Elsalam,M., Hussein,F., Meguid, N. A., El-Gindy,E.(1991):

               Clinical, biochemical and cytogenetic studies of mental retardation in
               Egyptian children. J. Publ.Health Assoc. Suppl.,189-199

  1. Meguid, N. A., Aboul-Ezz EH, Seif E, Temtamy SA.(1990): Heterozygous

               expression of Lesch-Nyhan syndrome: Clinical and ultrastrucural studies.
                J. Egypt Public Health Assoc. 65 (5-6): 585-600
               http://www.ncbi.nlm.nih.gov/pubmed/2134093

  1. Temtamy,S.A., Meguid, N. A. (1989): Hypogenitalism in the acrocallosal

               syndrome. Am. J. Med. Genet., 32:301-305.
               http://www.ncbi.nlm.nih.gov/pubmed/2658583

 

 
 

 

   
   
   
   

 

 

 

 

Grace is an initiative envisioned and funded by
the International Development Research Centre (IDRC), developed by Research For the Future (RFF) and managed by The GRACE Project Voluntary Association.
Grace est une initiative initiée et financée parle Centre de recherches pour le développement international (CRDI), développée par Research For the Future,
et gérée par l'Association Volontaire Projet de GRACE .