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NAGWA ABDEL MEGUID
Dr. Meguid is a professor of human genetics and head of the Department of Research on Children with Special Needs at the National Research Center (NRC) in Egypt. She holds a Ph.D. in Human Genetics, and she is a Senior Geneticist at the Genetics Institute, Pasadena, California; and a fellow of Uppsala University, Sweden. She was one of five selected scientists to win the outstanding L’Oreal UNESCO Award for women in Science for Africa and the Middle East (2002). She has used her expertise to identify and describe several novel genetic syndromes. She added new syndromes to the medical literature. She was given the Distinctive Arab Female Scientist Prize, Creative Women in Genetics, by the Arabian Gulf University, Bahrain, May, 2009. She was also given the National Award for Scientific Excellence in Advanced Technology in 2009. Furthermore, she was awarded the National Research Centre Appreciation Prize in Medical Sciences in 2011.
Dr. Meguid is the head and running a clinic for children with special needs in the NRC. She is one of the pioneers who accurately diagnosed, delineated and published autosomal recessive disorders in Egyptians as a consequence of the high prevalence of consanguinity. On the other hand she is the head of the laboratory of research in DNA and biochemical changes in genetic disorders. She participated in determining the spectrum of gene mutations causing common genetic disorders in Egypt (phenylketonuria, Duchenne muscular dystrophy, congenital sensorineural hearing loss and fragile-X syndrome) thus suggesting programs for their prevention by heterozygous detection and prenatal diagnosis. She is the first to delineate the prevalence of FX mutation among Egyptian males which was 0.9 per 1000. Moreover, it was 6.4% among mentally subnormal males.
In addition, Prof. Meguid initiated a special clinic for early intervention in the Medical Service Unit at the National Research Centre. She applied special evaluation programs to teach and assess the cognitive, language and motor skills.
Prof. Meguid is actively involved in training and teaching young physicians and scientists through a number of teaching and administrative posts. She also reaches out to her community by offering lectures to parents, schools and health care workers in Cairo and distant governorates and writing newspaper articles and on-line especially for women to increase awareness of genetic disorders and the value of genetic counseling. "As the mysteries of the human genetic code are unraveled, women need protection so that breakthroughs are used to treat and heal, not to isolate and discriminate." Dr. Nagwa Abdel Meguid writes of the potential for unethical use of genetic information and calls for strict guidelines to ensure privacy for individuals and knowledge-sharing for scientists.
Dr. Nagwa Meguid, a professor of human genetics, uses her field as an example of what women can accomplish for science, for society and themselves. Genetics also happens to be the science that proved women are just as capable as men.
She is a member in the National Committee for Women in Science and Technology, member of the International Jury L’OREAL-UNESCO Awards "For Women in Science" 2008 - 2011. She has extensive experience in training postgraduate students. She supervised around 25 PhD students and 27 master theses in medicine and neuroscience, human genetics and psychiatry. She has more than 130 national and international publications in the field of neuroscience and human genetics. She is a peer reviewer for scientific journals such as; Disease Marker Journal and Neuroscience Letters as well as being a member of TOWAS, and of the Neuroinsight Foundation for Brain Research Initiatives, Canada. She is the principal Investigator of the Canadian- Egyptian Neurodevelopmental Study, and a member of Gender Research in Africa into Information Communication Technologies for Empowerment (GRACE), International Development Research Centre in Canada (IDRC). She is a member of the Bioethics Network on Women's Issues in the Arab Region, 2011, and editorial board member of Autism-Open Access, OMICS Publishing group; An Open Access Publisher for Advancement of Science and Technology.
Recently, Dr Meguid shared in the discovery of inactivating mutations in the gene BCKDK (Branched Chain Ketoacid Dehydrogenase Kinase) in consanguineous families with autism, epilepsy and intellectual disability. BCKDK knockout mice showing abnormal brain amino acid profiles and autistic neurobehavioral deficits that respond to dietary supplementation. Thus, autism presenting with intellectual disability and epilepsy caused by BCKDK mutations represents a potentially treatable syndrome (September 7, 2012 http://www.sciencemag.org/content/current).
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Selected Main International Publications:
- Gaia Novarino, Paul El-Fishawy, Hulya Kayserili, Nagwa A. Meguid, Eric M. Scott, Jana Schroth, Jennifer L. Silhavy, Majdi Kara, Rehab O. Khalil, Tawfeg Ben-Omran, A. Gulhan Ercan-Sencicek, Adel F. Hashish, Stephan J. Sanders, Abha R. Gupta, Hebatalla S. Hashem, Dietrich Matern, Stacey Gabriel, Larry Sweetman, Yasmeen Rahimi, Robert A. Harris, Matthew W. State, Joseph G. Gleeson (2012) "Mutations in BCKD-kinase Lead to a Potentially Treatable Form of Autism with Epilepsy." Science Sep 6. http://www.ncbi.nlm.nih.gov/pubmed/22956686
- Meguid N (2012) "The Link between Genetic Abnormalities in the Monogenic Disorders and the Behavioral Phenotype of Polygenic Disorders Has Yet To Be Addressed in Research." Autism--Open Access. 2:1 http://dx.doi.org/10.4172/2165-7890.1000e103.
- Yamamah G, Abdel-Raouf E, Talaat A, Saad-Hussein A, Hamamy H, Meguid NA (2012) "Prevalence of consanguineous marriages in south Sinai, Egypt." J Biosoc Sci. May 14:1-9. http://www.ncbi.nlm.nih.gov/pubmed/22583662
- Alyaa Kotby, Mona Anwar, Ola Abd El-Aziz El-Masry, Mostafa Awady, Ali El-Nashar, Nagwa Meguid (2012) "Genetic Variants in the Methylenetetrahydrofolate Reductase Gene in Egyptian Children with Conotruncal Heart Defects and their Mothers." Macedonian Journal of Medical Sciences. Mar 15; 5(1):78-84. http://www.doaj.org/doaj?func=abstract&/id=972657
- Meguid NA, Fahim C, Sami R, Nashaat NH, Yoon U, Anwar M, El-Dessouky HM, Shahine EA, Ibrahim AS, Mancini-Marie A, Evans AC (2012): "Cognition and lobar morphology in full mutation boys with fragile X syndrome." Brain Cogn. 2012 Feb; 78(1):74-84. doi: 10.1016/j.bandc.2011.09.005. http://www.ncbi.nlm.nih.gov/pubmed/22070923
- Hamed RR, Maharem TM, Meguid, N. A., Sabry GM, Abdalla AM, Guneidy RA. (2011) "Purification and biochemical characterization of glutathione S-transferase from Down Syndrome and normal children erythrocytes: A comparative study." Res Dev Disabil 32(5):1470-82. http://www.ncbi.nlm.nih.gov/pubmed/21377322
- Meguid, N. A., Fahim C, Uicheul Y, Nashaat N, Samir A, Mancini-Marie A, Brandner C, Evans AC. (2010) "Brian morphology in autism and Fragile X Syndrome correlates with Social IQ." J Child Neurol. 25 (5):599-608 http://www.ncbi.nlm.nih.gov/pubmed/20110214
- Meguid, N. A., Adel Ferig Hashish, Mona Anwar, Gloria Sidhom (2010) "Assessment of 25-Hydroxy and 1, 25-Dihydroxy Vitamin D in Egyptian Children with Autism." J Altern Complement Med. 16 (6):641-5. http://www.ncbi.nlm.nih.gov/pubmed/20569030
- Meguid, N. A., Ahmed A. Dardir , Ehab R. Abdel-Raouf & Adel Hashish (2010) "Evaluation of Oxidative Stress in Autism: Defective Antioxidant Enzymes and Increased Lipid Peroxidation." Biol Trace Elem Res, accepted for publication. http://www.ncbi.nlm.nih.gov/pubmed/20845086
- Meguid, N. A., Dardir AA, El-Sayed EM, Ahmed HH, Hashish AF, Ezzat A.(2010) "Homocysteine and oxidative stress in Egyptian children with Down syndrome." Clin Biochem. 43(12): 963-967. http://www.ncbi.nlm.nih.gov/pubmed/20450901
- Mostafa K. , Amr M. Karim, Laila S.Hanna, Lamia A. El Husseiny, Medhat El Sahar, Hanan A. Abdel Menem, Meguid, N. A. (2009) "Methylenetetrahydrofolate reductase gene olymorphisms & risk of colorectal carcinoma in a sample of Egyptian individuals." Cancer Biomarkers, 5: 1-8. http://www.ncbi.nlm.nih.gov/pubmed/20037199
- Cherine Fahim, Meguid, N. A., Alan C Evans (2009) "Anterior to posterior limb of the internal capsule morphology in fragile X syndrome." Developmental Medicine & Child Neurology, 51: 838?842 http://www.ncbi.nlm.nih.gov/pubmed/19747282
- Meguid, N. A., Hazem M. Atta, Amr S.Gouda , Rehab O .Khalil (2008) "Role of polyunsaturated fatty acids in the management of Egyptian Children with Autism." J Clinical Biochemistry, 41: 1044?1048. http://www.ncbi.nlm.nih.gov/pubmed/18582451
- Meguid, N. A., Ahmed A. Dardir, Mohamed Khass, Lamia Hossieny, Afaf Ezzatc ; Mostafa K. El Awady (2008) "MTHFR genetic polymorphism as a risk factor in Egyptian mothers with Down syndrome children." Disease Markers, 24(1):19-26. http://www.ncbi.nlm.nih.gov/pubmed/18057532
- Bassam R. Ali, Steve Jeffery, Neha Patel, Meguid, N. A., Michael A.Patton, Ali R. Afzal (2007) "Novel Robinow syndrome causing mutations in the frizzled-like domain of ROR2 are retained in the endoplasmic reticulum." Human Genetics, 122:389?39. http://www.ncbi.nlm.nih.gov/pubmed/17665217
- Meguid, N. A., Katoury,A., Abdel-Salam,G, Ruby,M., Afifi,H. (2004) "Growth Charts for Egyptian children with Down syndrome: (0-36 months)." Eastern Mediterranean Health Journal, 10:106-115. http://www.ncbi.nlm.nih.gov/pubmed/16201715
- Abdel Salam,GH.; Zaki,M.; Lebon P.; Meguid, N. A. (2004) "Aicardi-Goutieres syndrome: Clinical and neuroradiological findings of new 10 cases." Acta Paediatr 93: 929-936, 2004 http://www.ncbi.nlm.nih.gov/pubmed/15303808
- El-Awad, M.; El-Shater, S.; Ragaa, E.; Atef, K.; Meguid, N. A. (2004) "Molecular study on Y chromosome microdeletions in Egyptian males with idiopathic infertility." Asian J. Androl, 6: 53- http://www.biomedexperts.com/Profile.bme/361520/Mostafa
- Meguid, N. A., Tentany,A., Mazen,I (2003) "Transposition of external genitalia and associated malformations." Clinical Dysmorphology, 11: 1-5. http://www.ncbi.nlm.nih.gov/pubmed/12514368
- Meguid, N. A., Ashour, A. (2001) "Holoprosencephaly and split Hand/foot: Additional case with this rare association." Clinical Dysmorphology, 10(4): 277-280. http://www.ncbi.nlm.nih.gov/pubmed/11666003
- Meguid, N. A., Afifi,H., Khoulosy,N. (2001) "Evaluations of SOD,GTpx enzymes and Cu,Ze,Sel trace elements in Egyptian Children with DS." Biological Trace Element Research, 81: 21- 28. http://www.ncbi.nlm.nih.gov/pubmed/11508329
- Meguid, N. A., Zaki,M, Hammad,S. (2001) "Premarital investigation: Effect of genetic counselling." Eastern Mediterranean Health J, 6, 2:652-66. http://www.ncbi.nlm.nih.gov/pubmed/11794071
- Effat,L., Harouni,A., Khalda M., Meguid, N. A. (2000) "Screening of Dysrophin gene deletions in Egyptian Patients with DMD muscular dystrophies." Disease Markers, 16(3-4):125-129. http://www.ncbi.nlm.nih.gov/pubmed/11381192
- Temtamy,S.A., Ismail,S., Meguid, N. A. (2000) "Lenz microphthalmia syndrome: Three additional cases with rare associated anomalies." Genetic Counseling, 11, (2), 147-152 http://www.ncbi.nlm.nih.gov/pubmed/10893665
- Bassyouni H., Afifi H, El-Awady M, Meguid, N. A. (2000) "Mucopolysaccharidosis type I: Clinical & biochemical Study." Eastern Mediterranean Health Journal, 6, 2/3: 359-366. http://www.ncbi.nlm.nih.gov/pubmed/11556024
- Effat,L., Kuzmin,A., Kasem,N, Meguid, N. A., Kotb, S.,Eisensmith,L, Temtamy,S., Rushdi, S., Woo, S., El-Awady, M. (1999) "Haplotypes and mutations of the PAH locus in Egyptian families with PKU." European J. of Human Genetics, 2. 259-262. http://www.ncbi.nlm.nih.gov/pubmed/10196714
- Temtamy,S.A., Meguid, N. A., Ismail,S.I., Ramzy,M.I. (1998) "A new multiple congenital anomaly, mental retardation syndrome with preaxial brachydactyly, hyperphalangism, deafness and orodental anomalies." Clin Dysmorphol, 7 (4): 249-255. http://www.ncbi.nlm.nih.gov/pubmed/9823490
- Meguid, N. A., Afifi,H.H., Ramzy,M.I., Hindawy,A., Temtamy,S.A.(1997)" GAPO syndrome: First Egyptian case with ultrastructural changes in the gingiva." Clin. Genet. 52: 110-115. http://www.ncbi.nlm.nih.gov/pubmed/9298746
- Temtamy,S.A., Meguid, N. A., Mahmoud,A., Afifi,H., Gerzawy,A., Zaki,M. (1996) "COFS syndrome with familial 1;16 translocation." Clin. Genet. 50: 240-243. http://www.ncbi.nlm.nih.gov/pubmed/9001808
- Temtamy,S.A., Kandil,M.R., Demerdash,A.M., Hassan,W.A., Meguid, N.A., Afifi,H. H. (1994) "An epidemiological/genetic study of mental subnormality in Assiut Governorate Egypt." Clin. Genet. 46:347-351. http://www.ncbi.nlm.nih.gov/pubmed/7889643
- Temtamy,S.A., Aboul-Ezz,E., Sinbawy A; Meguid N (1994) "Orodental, ear and eye anomalies in Egyptian Brachmann de Lange syndrome." The J. of the Egyptian Public Health Association, LXIX (3-4): 163-183. http://www.ncbi.nlm.nih.gov/pubmed/17265636
- Meguid, N. A. (1993) "Frontonasal dysplasia, lipoma of the corpus callosum and tetralogy of Fallot." Clin.Genet. 44: 95-97. http://www.ncbi.nlm.nih.gov/pubmed/8275566
- Meguid, N. A., Habibian,R. (1992) "Isodicentric chromosome 18 in an abnormal infant using chromosome specific DNA probe." Clin. Genet. 41: 225-228. http://www.ncbi.nlm.nih.gov/pubmed/1606710
- Meguid, N. A., Temtamy,S.A. (1991) "Neu-Laxova syndrome in two Egyptian families." Am. J. Med. Genet. 41:30-31. http://www.ncbi.nlm.nih.gov/pubmed/1951459
- Meguid, N. A., Aboul-Ezz EH, Seif E, Temtamy SA.(1990) "Heterozygous expression of Lesch-Nyhan syndrome: Clinical and ultrastrucural studies." J. Egypt Public Health Assoc. 65 (5-6): 585-600. http://www.ncbi.nlm.nih.gov/pubmed/2134093
- Temtamy,S.A., Meguid, N. A.,(1989) "Hypogenitalism in the acrocallosal syndrome." Am. J. Med. Genet., 32:301-305. http://www.ncbi.nlm.nih.gov/pubmed/2658583